Anti-IFI30 antibody

Anti-IFI30 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to IFI30

IHC-P

Human IFI30

gamma-interferon-inducible lysosomal thiol reductase antibody; gamma-interferon-inducible lysosomal thiol reductase antibody; gamma-interferon-inducible protein IP-30 antibody; gamma-interferon-inducible protein IP-30 antibody; GILT antibody; GILT antibody; IFI-30 antibody; interferon gamma-inducible protein 30 preproprotein antibody; IP30 antibody; IP30 antibody; legumaturain antibody; lysosomal thio reductase IP30 antibody; lysosomal thiol reductase IP30 antibody; MGC32056 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human IFI30 (rh IFI30; P13284; Met1-Lys243).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

IFI30 belongs to the GILT family. This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284 and Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction. IFI30 is a lysosomal thiol reductase that can reduce protein disulfide bonds. It facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. It also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. IFI30 may facilitate the complete unfolding of proteins destined for lysosomal degradation and plays an important role in antigen processing.

• Haque MA, et al. (2002) Absence of gamma-Interferon-inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes. J Exp Med. 195(10):1267-77.
• Phan UT, et al. (2000) Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. J Biol Chem. 275(34):25907-14.
• Phan UT, et al. (2001) Multiple species express thiol oxidoreductases related to GILT. Immunogenetics. 53(4):342-6.