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GALC antibody

Cat.#: 110834

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Product Information

  • Product Name
    GALC antibody
  • Documents
  • Description
    GALC Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 30 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    GalactOCerebrosidase antibody; galactosylceramidase antibody; GALC antibody; GALCERase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of GALC recombinant protein (Accession Number: BC036518). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110834(GALC antibody) at dilution of 1:200

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110834(GALC antibody) at dilution of 1:200

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:110834(GALC antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:110834(GALC antibody) at dilution of 1:50 (under 10x lens)

  • Background
    Galactosylceramidase (Galc) is a lysosomal enzyme involved in the catabolism of galactosylceramide, a major lipid in myelin, kidney, and epithelial cells of the small intestine and colon. The normal GALC mRNA encodes the 80 kDa precursor, which is processed into 50 and 30 kDa subunits. Mutation of GALC gene will lead to Krabbe disease (globoid cell leukodystrophy), an autosomal recessive neurodegenerative disorder that affects both the central and peripheral nervous system due to an enzymatic defect of galactocerebrosidase. This antibody is specific to GALC.
  • References
    • Hossain MA, Otomo T, Saito S. Late-onset Krabbe disease is predominant in Japan and its mutant precursor protein undergoes more effective processing than the infantile-onset form. Gene. 534(2):144-54. 2014.
    • Hossain MA, Higaki K, Saito S. Chaperone therapy for Krabbe disease: potential for late-onset GALC mutations. Journal of human genetics. 60(9):539-45. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"