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Product Name
GAD2 antibody
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Description
GAD2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IP detected in rat brain tissue. Observed molecular weight by Western-blot: 65 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
GAD 65 antibody; GAD2 antibody; GAD65 antibody; Glutamate decarboxylase 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of GAD2 recombinant protein (Accession Number: NM_001134366). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110817(GAD2 Antibody) at dilution of 1:600
IP Result of anti-GAD2 (IP:Catalog No:110817, 3ug; Detection:Catalog No:110817 1:300) with rat brain tissue lysate 4000ug.
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Background
GAD2, also named as GAD65, belongs to the group II decarboxylase family. GAD2 catalyzes the production of GABA. It is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD2is expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and insulin secretion. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2. The antibody is specific to GAD2.
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