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FXYD6 antibody

Cat.#: 110757

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Product Information

  • Product Name
    FXYD6 antibody
  • Documents
  • Description
    FXYD6 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue, human liver tissue, human ovary tissue, human skin tissue, human spleen tissue, human testis tissue. Positive FC detected in SH-SY5Y cells. Positive WB detected in human brain tissue, human testis tissue, mouse brain tissue, PC-12 cells, rat brain tissue. Observed molecular weight by Western-blot: 20 kDa
  • Tested applications
    ELISA, WB, IHC, FC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FXYD6 antibody; Phosphohippolin antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FXYD6 recombinant protein (Accession Number: NM_001164832). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110757(FXYD6 antibody) at dilution of 1:400

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:110757(FXYD6 antibody) at dilution of 1:400

    1X10^6 SH-SY5Y cells were stained with 0.2ug FXYD6 antibody (Catalog No:110757, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

    1X10^6 SH-SY5Y cells were stained with 0.2ug FXYD6 antibody (Catalog No:110757, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110757(FXYD6 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110757(FXYD6 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110757(FXYD6 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110757(FXYD6 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    The FXYD family is a group of small single-span transmembrane proteins characterized by a signature sequence containing an FXYD motif, two conserved glycines and a serine residue. Members of the FXYD family, including FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (Mat8), FXYD4 (CHIF), FXYD5 (RIC), FXYD6 (phosphohippolin) and FXYD7, are tissue specific regulators of the Na,K-ATPase. FXYD6 is primarily expressed in the brain. It modulates the kinetic activity of Na,K-ATPase and has long-term physiological importance in maintaining cation homeostasis. It may play a role in endolymph composition, and has a potential important role in neuronal excitability of the CNS during postnatal development and in the adult brain. On the SDS-PAGE FXYD6 migrates with an apparent molecular weight of approximately 20 kDa, which is larger than the calculated molecular weight of 10.5 kDa (PMID: 15193427; 17209044). The gene encodes FXYD6 is located on chromosome 11q23.3, and it might be a susceptibility gene of schizophrenia.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"