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FRS2 antibody

Cat.#: 107224

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Special Price 239.0 USD

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Product Information

  • Product Name
    FRS2 antibody
  • Documents
  • Description
    FRS2 Mouse Monoclonal antibody. Positive WB detected in MCF-7 cells, HEK-293 cells, HeLa cells. Positive IF detected in MCF-7 cells. Observed molecular weight by Western-blot: 68 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    FGFR signaling adaptor SNT antibody; FGFR substrate 2 antibody; FRS2 antibody; FRS2A antibody; FRS2alpha antibody; SNT antibody; SNT 1 antibody; SNT1 antibody
  • Isotype
    Mouse IgG3
  • Preparation
    This antibody was obtained by immunization of FRS2 recombinant protein (Accession Number: NM_006654). Purification method: Protein A purified.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:20-1:200

  • Validations

    MCF-7 cells were subjected to SDS PAGE followed by western blot with (FRS2 Antibody) at dilution of 1:1000

    MCF-7 cells were subjected to SDS PAGE followed by western blot with (FRS2 Antibody) at dilution of 1:1000

    Immunofluorescent analysis of (-20oc Ethanol) fixed MCF-7 cells using Catalog No:107224(FRS2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)

    Immunofluorescent analysis of (-20oc Ethanol) fixed MCF-7 cells using Catalog No:107224(FRS2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L)

  • Background
    Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) has an alternative name as SNT-1, it is an adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. FRS2 is a 508 amino-acid protein,which is phosphorylated on tyrosine residues. The molecular weight of non-phosphorylated FRS2 is 57-68 kDa, but phosphorylated FRS2 is 80-90 kDa. Phosphorylation of FRS2 is associated with activation of a number of MAP kinases. Allele-specific regulation of FGFR2 mRNA expression with a mildly increased breast cancer risk has been reported.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"