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Human FRZB / sFRP-3 (His Tag) recombinant protein

Cat.#: 500491

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Product Information

  • Product Name
    Human FRZB / sFRP-3 (His Tag) recombinant protein
  • Documents
  • Description
    FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
  • Protein name
    Frizzled-related protein
  • Protein short names
    OS1; FREZZLED; SRFP3; FRP-3; FRP; FZRB; FRZB1; FRITZ; RP23-33L19.1 ; SFRP3; HFIZ; FRZB-1; FRZB-PEN; FRE; FRZB1; FRP-3-1
  • Uniprot ID
    Q92765
  • Gene Name
    FRZB; hCG_21961
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FRZB comprises 304 amino acids and has a predicted molecular mass of 34.5 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Validations

    Human FRZB / sFRP-3 Protein (His Tag) SDS-PAGE

    Human FRZB / sFRP-3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"