-
Product Name
Human Frizzled-5/FZD5 (His & Fc Tag) recombinant protein
- Documents
-
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.
-
Protein name
Frizzled-5
-
Protein short names
MFZ5; DKFZP434E2135; FZ-5; FZD5; FRIZZLED-5; FZ5; MGC141642; AI427138; MGC129692; C2ORF31; 5330434N09RIK; HFZ5
-
Uniprot ID
Q13467
-
Gene Name
FZD5; C2orf31
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Pro 167) of human frizzled 5 (NP_003459.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human frizzled 5/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 389 amino acids and has a predicted molecular mass of 44 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhfrizzled 5/Fc monomer is approximately 58 kDa due to glycosylation.
-
Purity
> 97 % as determined by SDS-PAGE
-
Validations
Human Frizzled-5 / FZD5 Protein (His & Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"