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Product Name
Mouse Frizzled-5/FZD5 (Fc Tag) recombinant protein
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Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4.
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Protein name
Frizzled-5
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Protein short names
FZD5; FRIZZLED-5; FZ-5; MFZ5; DKFZP434E2135; MGC129692; C2ORF31; 5330434N09RIK; HFZ5; MGC141642; FZ5; AI427138
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Uniprot ID
Q9EQD0
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Gene Name
Fzd5
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Source/Expression Host
CHO Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse FZD5 (Q9EQD0) (Met1-Pro167) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse FZD5 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 382 amino acids and has a predicted molecular mass of 42.9 kDa. The apparent molecular mass of the protein is approximately 52-56 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse Frizzled-5 / FZD5 Protein (Fc Tag) SDS-PAGE
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