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Product Name
Mouse Frizzled-1/FZD1 (His Tag) recombinant protein
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Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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Protein name
Frizzled-1
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Protein short names
FZD1; FRIZZLED-1; FZ-1; DKFZP564G072; AW227548; FZ1; FLJ95923
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Uniprot ID
O70421
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Gene Name
Fzd1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse FZD1 (NP_067432.2) extracellular domain (Met 1-His 248) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse FZD1 pro form consists of 191 amino acids and has a predicted molecular mass of 21 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FZD1 is approximately 35-40 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse Frizzled-1 / FZD1 Protein (His Tag) SDS-PAGE
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