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FOXO4 antibody

Cat.#: 110706

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Product Information

  • Product Name
    FOXO4 antibody
  • Documents
  • Description
    FOXO4 Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue, mouse uterus tissue. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 65kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    AFX antibody; AFX1 antibody; forkhead box O4 antibody; Forkhead box protein O4 antibody; FOXO4 antibody; MLLT7 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of FOXO4 recombinant protein (Accession Number: NM_005938). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110706(FOXO4 antibody) at dilution of 1:500

    mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110706(FOXO4 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:110706(FOXO4 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:110706(FOXO4 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:110706(FOXO4 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:110706(FOXO4 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. The antiboay can recognize isoform 1 and isoform Zeta of FOXO4.
  • References
    • Xu X, Fan Z, Kang L. Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. The Journal of clinical investigation. 123(2):630-45. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"