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Product Name
Fibrinogen gamma chain antibody
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Description
Fibrinogen gamma chain Rabbit Polyclonal antibody. Positive WB detected in human spleen tissue, human liver tissue. Positive IHC detected in human hepat℃irrhosis tissue. Observed molecular weight by Western-blot: 52 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FGG antibody; fibrinogen gamma chain antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Fibrinogen gamma chain recombinant protein (Accession Number: NM_000509). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:110657(FGG antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using Catalog No:110657(FGG Antibody) at dilution of 1:50 (under 40x lens)
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Background
Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.
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References
- Krishnamoorthy A, Ajay AK, Hoffmann D. Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 118(7):1934-42. 2011.
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