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  • Fibrinogen-Binding Inhibitor Peptide

Fibrinogen-Binding Inhibitor Peptide

Not For Human Use, Lab Use Only.

Cat.#: 301553

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Fibrinogen-Binding Inhibitor Peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    HHLGGAKQAGDV
  • Sequence
    H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    97.5%
  • Molecular Formula
    C50H80N18O16
  • Molecular Weight
    1189.3
  • CAS No.
    89105-94-2
  • Source
    Synthetic
  • Form
    Powder
  • Description
    This synthetic dodecapeptide represents the specific platelet receptor recognition site of the human fibrinogen γ chain (residues 400-411). It is a potent inhibitor of the binding of fibrinogen, fibronectin, and von Willebrand factor to thrombin- or ADP-stimulated platelets. The peptide has also been used in studying phosphorylation processes associated with platelet activation.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • S.Timmons et al., Proc. Natl. Acad. Sci. USA, 81, 4935 (1984)
    • E.F.Plow et al., J. Biol. Chem., 259, 5388 (1984)
    • Z.M.Ruggeri et al., Proc. Natl. Acad. Sci. USA, 83, 5708 (1986)
    • S.Williams and H.Gralnick, Thromb. Res., 46, 457 (1987)
    • J.E.Ferrell, Jr. and G.S.Martin, Proc. Natl. Acad. Sci. USA, 86, 2234 (1989)
    • R.R.Hantgan et al., Thromb. Haemost., 68, 694 (1992)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-HHLGGAKQAGDV-OH
  • Chemical Formula:C50H80N18O16
  • Sequence length:12
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:-0.58
  • Mw average:1189.27
  • Theoretical pI:7.88
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"