Fibrinogen beta chain antibody

Fibrinogen beta chain antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Fibrinogen beta chain Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in mouse heart tissue, mouse brain tissue, mouse kidney tissue, mouse liver tissue. Observed molecular weight by Western-blot: 47-56 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

FGB antibody; fibrinogen beta chain antibody

Rabbit IgG

This antibody was obtained by immunization of Fibrinogen beta chain recombinant protein (Accession Number: NM_005141). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGB is the beta chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide B is cleaved from FGB by thrombin. Mutations in the gene of FGB lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.

• Krishnamoorthy A, Ajay AK, Hoffmann D. Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 118(7):1934-42. 2011.