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Product Name
Fibrinogen beta chain antibody
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Description
Fibrinogen beta chain Mouse Monoclonal antibody. Positive WB detected in human heart tissue, fetal human brain tissue. Observed molecular weight by Western-blot: 48 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
FGB antibody; fibrinogen beta chain antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of Fibrinogen beta chain recombinant protein (Accession Number: NM_005141). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:107211(FGB Antibody) at dilution of 1:1000
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Background
Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA), beta (FGB), gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, the inflammatory response, wound healing, and neoplasia (PMID: 16102057). FGB is the beta chain of fibrinogen. During conversion of fibrinogen to fibrin, fibrinopeptide B is cleaved from FGB by thrombin. Mutations in the gene of FGB lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
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