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Product Name
FcRn-Specific antibody
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Description
FcRn-Specific Rabbit Polyclonal antibody. Positive WB detected in human placenta tissue, human liver tissue. Observed molecular weight by Western-blot: 35 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
alpha chain antibody; FCGRT antibody; FCRN antibody; Neonatal Fc receptor antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_004107). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
human placenta tissue were subjected to SDS PAGE followed by western blot with Catalog No:110606(FCGRT-Specific antibody) at dilution of 1:300
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Background
The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).
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References
- Struble EB, Ma L, Zhong L, Lesher A, Beren J, Zhang P. Human antibodies can cross guinea pig placenta and bind its neonatal Fc Receptor: implications for studying immune prophylaxis and therapy during pregnancy. Clinical & developmental immunology. 2012:538701. 2012.
- Xu Y, Ma L, Norton MG. Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs. Placenta. 36(12):1370-7. 2015.
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