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Product Name
Fc epsilon RI alpha antibody
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Description
Fc epsilon RI alpha Rabbit Polyclonal antibody. Positive WB detected in human spleen tissue, PC-3 cells. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
Fc epsilon RI alpha antibody; FCE1A antibody; FCER1A antibody; FcERI antibody; FceRIa antibody; IgE Fc receptor subunit alpha antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Fc epsilon RI alpha recombinant protein (Accession Number: NM_001387280). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:110567(FCER1A antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:110567(FCER1A antibody) at dilution of 1:100 (under 10x lens)
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Background
Fc fragment of IgE, high affinity I, receptor for, alpha polypeptide, also known as high affinity immunoglobulin epsilon receptor subunit alpha, FCER1A and FCE1A, is a single-pass type I membrane protein which contains 2 immunoglobulin-like domains. FCER1A is a subunit of the IgE receptor, which is composed of one glycosylated alpha (FCER1A), one beta (FCER1B), and two gamma (FCER1G) subunits. The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
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References
- Andersson CK, Mori M, Bjermer L, Löfdahl CG, Erjefält JS. Novel site-specific mast cell subpopulations in the human lung. Thorax. 64(4):297-305. 2009.
- Andersson CK, Bergqvist A, Mori M, Mauad T, Bjermer L, Erjefält JS. Mast cell-associated alveolar inflammation in patients with atopic uncontrolled asthma. The Journal of allergy and clinical immunology. 127(4):905-12.e1-7. 2011.
- Andersson CK, Tufvesson E, Aronsson D. Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology. Allergy. 66(12):1590-7. 2011.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"