FBXW5 antibody

FBXW5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

FBXW5 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, rat brain tissue. Positive IHC detected in human kidney tissue. Observed molecular weight by Western-blot: 65 kDa

ELISA, IHC, WB

Human,Mouse,Rat; other species not tested.

DKFZp434B205 antibody; Fbw5 antibody; FBXW5 antibody; RP11 229P13.10 antibody

Rabbit IgG

This antibody was obtained by immunization of FBXW5 recombinant protein (Accession Number: NM_018998). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins, and they are a family of eukaryotic proteins characterized by an approximately 40 amino acid motif. SCF complex, a class of ubiquitin ligases, consists of invariable components, Skp1 and Cullin, and variable components of F-box proteins, which have a primary role in determining substrate specificity. FBXW5 (F-box/WD repeat-containing protein 5) is a novel protein containing WD-40 repeats, which were frequently involved in protein-protein interactions. FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway. By forming different E3 ubiquitin-protein ligase complexes, FBXW5 mediates the polyubiquitination and subsequent degradation of TSC2 and centriolar protein HsSAS-6.