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Product Name
FAM107A antibody
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Description
FAM107A Rabbit Polyclonal antibody. Positive WB detected in Transfected HEK-293 cells. Positive IHC detected in human lung cancer tissue. Positive IF detected in MCF-7 cells.
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Tested applications
ELISA, IHC, IF, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
DRR1 antibody; FAM107A antibody; FLJ30158 antibody; FLJ45473 antibody; Protein FAM107A antibody; Protein TU3A antibody; TU3A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of FAM107A recombinant protein (Accession Number: NM_001076778). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:10-1:100
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Validations
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:110458(FAM107A antibody) at dilution of 1:50 (under 10x lens)
Immunofluorescent analysis of MCF-7 cells, using FAM107A antibody Catalog No:110458 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:110458(FAM107A Antibody) at dilution of 1:1000
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Background
FAM107A, also named as TU3A, encodes a 144 amino-acid protein, which contains a coiled-coil domain and a nuclear localization signal. FAM107A as a transcription factor regulates some gene transcription and signal transduction in cell. With the exception of peripheral blood cells, FAM107A is widely expressed in normal tissues, but shows significant loss of expression in renal cell carcinomas and frequent loss of expression in cervical, gastric, ovarian and non small cell lung cancers. Transfection of FAM107A mRNA into cancer cell line inhibits cell growth and proliferation, supporting the evidence that the gene functions as an important tumor suppressor.
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