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Product Name
Human GFER / ALR (His Tag) recombinant protein
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Description
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.
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Protein name
FAD-linked sulfhydryl oxidase ALR
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Protein short names
HPO1; ERV1; AUGMENTER OF LIVER REGENERATION; GROWTH FACTOR; ERV1 HOMOLOG; HEPATOPOIETIN PROTEIN; GFER; HPO2; ERV1-LIKE GROWTH FACTOR; HPO; HERV1; HSS; FAD-LINKED SULFHYDRYL OXIDASE ALR; HEPATIC REGENERATIVE STIMULATION SUBSTANCE; ALR
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Uniprot ID
P55789
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Gene Name
GFER; ALR; HERV1; HPO
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human GFER (P55789-2) (Met1-Asp125) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human GFER consists of 143 amino acids and predicts a molecular mass of 17.3 KDa. It migrates as an approximately 18 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human GFER / ALR Protein (His Tag) SDS-PAGE
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