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Product Name
EXOSC7 antibody
- Documents
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Description
EXOSC7 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human colon tissue. Positive WB detected in MCF-7 cells, A431 cells, COLO 320 cells, HEK-293 cells, HeLa cells, HepG2 cells, Jurkat cells, K-562 cells. Observed molecular weight by Western-blot: 37 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
EAP1 antibody; EXOSC7 antibody; exosome component 7 antibody; FLJ26543 antibody; hRrp42p antibody; KIAA0116 antibody; RRP42 antibody; Rrp42p antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of EXOSC7 recombinant protein (Accession Number: XM_047447748). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:110413(EXOSC7 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:110413(EXOSC7 Antibody) at dilution of 1:50 (under 40x lens)
Immunohistochemistry of paraffin-embedded human colon tissue slide using Catalog No:110413(EXOSC7 Antibody) at dilution of 1:50 (under 40x lens)
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Background
In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. EXOSC7 also named as RRP42 or EAP1 is a 291 amino acid protein, which belongs to the RNase PH family. EXOSC7 is one of the six RNase-PH domain subunits of the exosome and required for the processing of the 7S pre-RNA
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