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Product Name
Human SULT1E1 (His Tag) recombinant protein
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Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
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Protein name
Estrogen sulfotransferase
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Protein short names
EST; EST-1; SULT1E1; MGC34459; ST1E1; STE
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Uniprot ID
Q53X91
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Gene Name
SULT1E1; STE
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SULT1E1 (NP_005411.1) (Asn 2-Ile 294) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SULT1E1 comprises 300 amino acids and has a predicted molecular mass of 36 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Validations
Human SULT1E1 / ST1E1 Protein (His Tag) SDS-PAGE
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