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Product Name
ESR2 Beta-6 antibody
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Description
ESR2 Beta-6 Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue. Positive IHC detected in human cervix tissue. Observed molecular weight by Western-blot: 42 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
ER BETA antibody; Erb antibody; ESR BETA antibody; ESR2 antibody; ESRB antibody; ESTRB antibody; estrogen receptor 2 (ER beta) antibody; Estrogen receptor beta antibody; NR3A2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001437). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:110476(ESR2 Beta-6 Antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human cervix using Catalog No:110476(ESR2 Beta-6 antibody) at dilution of 1:50 (under 40x lens)
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Background
Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. It binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
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