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Product Name
ERLIN1 Polyclonal Antibody
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Description
Polyclonal antibody to ERLIN1
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Tested applications
WB, IHC
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Species reactivity
Human
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Alternative names
ERLIN1 antibody; C10orf69 antibody; Erlin-1 antibody; KE04 antibody; KEO4 antibody; SPFH1 antibody; SPG62 antibody; erlin-1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human ERLIN1
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200 -
Validations
Western blot - ERLIN1 Polyclonal Antibody
Western blot analysis of extracts of COLO320 cells, using ERLIN1 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"