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Product Name
ERAP2 antibody
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Description
ERAP2 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue. Positive WB detected in K-562 cells, A549 cells, mouse thymus tissue. Observed molecular weight by Western-blot: 61-65 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
ERAP2 antibody; FLJ23633 antibody; FLJ23701 antibody; FLJ23807 antibody; L RAP antibody; LRAP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ERAP2 recombinant protein (Accession Number: NM_001329229). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110400(ERAP2 antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:110400(ERAP2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:110400(ERAP2 antibody) at dilution of 1:50 (under 40x lens)
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Background
ERAP2(Endoplasmic reticulum aminopeptidase 2) is also named as LRAP(Leukocyte-derived arginine aminopeptidase) and belongs to the peptidase M1 family. It plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. It can form heterodimers with ERAP1(PMID:15908954). It has 4 isoforms produced by alternative splicing. And defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.
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