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Product Name
Human EDEM2 / C20orf31 (His Tag) recombinant protein
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Description
Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
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Protein name
ER degradation-enhancing alpha-mannosidase-like protein 2
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Protein short names
C20ORF49; ER DEGRADATION ENHANCER; C20ORF31; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE 2; UNQ573/PRO1135; EDEM2; RP23-388H13.1; 9530090G24RIK; MANNOSIDASE ALPHA-LIKE 2; ER DEGRADATION-ENHANCING-MANNOSIDASE-LIKE PROTEIN 2; AI327354; BA4204.1; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2
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Uniprot ID
Q9BV94
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Gene Name
EDEM2; C20orf31; C20orf49; UNQ573/PRO1135
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human EDEM2 (AAH01371.1) (Met1-Lys492) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human EDEM2 consists of 482 amino acids and predicts a molecular mass of 54 KDa. It migrates as an approximately 53-58 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human EDEM2 / C20orf31 Protein (His Tag) SDS-PAGE
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