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SIV SIV-GP120 / Glycoprotein 120 (His Tag)

Cat.#: 501986

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Product Information

  • Product Name
    SIV SIV-GP120 / Glycoprotein 120 (His Tag)
  • Documents
  • Description
    The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity).
  • Protein name
    Envelope glycoprotein gp160
  • Protein short names
    SU; gp120; TM; gp32
  • Uniprot ID
    P12492
  • Gene Name
    env
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the SIV envelope glycoprotein gp160 (CAA32487.1) extracellular domain (Gln24-Arg531),termed as gp120, was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    SIV
  • Molecular weight
    The recombinant SIV envelope glycoprotein gp120 consists 519 amino acids and predicts a molecular mass of 59.8 kDa.
  • Purity
    > 85 % as determined by SDS-PAGE.
  • Validations

    Simian immunodeficiency virus (SIV) envelope glycoprotein gp160 Protein (His Tag)

    Simian immunodeficiency virus (SIV) envelope glycoprotein gp160 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"