EMILIN1 antibody

EMILIN1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

EMILIN1 Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor. Positive WB detected in human kidney tissue, human brain tissue, human placenta tissue. Observed molecular weight by Western-blot: 120kd

ELISA, WB, IHC

human; other species not tested.

EMILIN1 antibody; gp115 antibody; EMILIN antibody; DKFZp586M121 antibody; EMILIN 1 antibody

Rabbit IgG

This antibody was obtained by immunization of EMILIN1 recombinant protein (Accession Number: BC007530). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

EMILIN1, also named as EMILIN, EMILIN-1, gp115 and EMI, may be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. It has cell adhesive capacity. EMILIN1 is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis. ( PMID:20186130 ) EMILIN1 may play a key role in hypertensive vascular remodeling. TGFβ proteins are the main regulators of blood vessel development and maintenance, and EMILIN1 inhibits TGFβ signaling by binding specifically to the proTGFβ precursor and preventing its maturation by furin convertases in the extracellular space.(PMID:19922630 )

• Lee GY, Haverty PM, Li L. Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer research. 74(11):3114-26. 2014.