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Product Name
ELP3 Polyclonal Antibody
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Description
Polyclonal antibody to ELP3
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Tested applications
WB, IHC
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Species reactivity
Human, Mouse, Rat
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Alternative names
ELP3 antibody; KAT9 antibody; elongator complex protein 3 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 358-547 of human ELP3 (NP_060561.3).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200 -
Validations
Western blot - ELP3 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using ELP3 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 10s.
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human lung cancer using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human liver cancer using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human colon carcinoma using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human breast cancer using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human gastric cancer using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded mouse lung using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded mouse spleen using ELP3 antibody at dilution of 1:200 (40x lens).
Immunohistochemistry - ELP3 Polyclonal Antibody
Immunohistochemistry of paraffin-embedded mouse kidney using ELP3 antibody at dilution of 1:200 (40x lens).
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Background
Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin. May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"