ELAVL2 Rabbit Polyclonal antibody. Positive WB detected in mouse cerebellum tissue. Positive IP detected in mouse cerebellum tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 38-45 kDa
ELISA, WB, IHC, IP
Human,Mouse,Rat,Zebrafish; other species not tested.
ELAV like neuronal protein 1 antibody; ELAV like protein 2 antibody; ELAV2 antibody; ELAVL2 antibody; HEL N1 antibody; HELN1 antibody; Hu antigen B antibody; HUB antibody
This antibody was obtained by immunization of ELAVL2 recombinant protein (Accession Number: BC030692). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:110273(ELAVL2 antibody) at dilution of 1:3000
Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-ELAVL2 (IP:Catalog No:110273, 4ug; Detection:Catalog No:110273 1:1000) with mouse cerebellum tissue lysate 4400ug.
The ELAV (embryonic lethal abnormal visual system) gene of D. Melanogaste is the the first identified member of a family of neuronal RNA binding proteins that is conserved in metazoans. The proteins in this family contain three RNA Recognition Motifs (RRM), with a hinge region separating the second and third RRMs and an optional non-conserved N-terminal region. The hinge includes signals essential for nuclear export and subcellular localization [PMID:9874760]. Elav is expressed specifically in the neurons and is required for the correct development and maintenance of the nervous system. ELAVL2 can binds RNA, and recognize a GAAA motif. In addition, it can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR[PMID:18715504,21695151].
- Parchem RJ, Moore N, Fish JL. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell reports. 12(5):760-73. 2015.
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