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  • ELAVL2 antibody
  • ELAVL2 antibody
  • ELAVL2 antibody
  • ELAVL2 antibody

ELAVL2 antibody

Cat.#: 110273

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Special Price 239.0 USD

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Product Information

  • Product Name
    ELAVL2 antibody
  • Documents
  • Description
    ELAVL2 Rabbit Polyclonal antibody. Positive WB detected in mouse cerebellum tissue. Positive IP detected in mouse cerebellum tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 38-45 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat,Zebrafish; other species not tested.
  • Alternative names
    ELAV like neuronal protein 1 antibody; ELAV like protein 2 antibody; ELAV2 antibody; ELAVL2 antibody; HEL N1 antibody; HELN1 antibody; Hu antigen B antibody; HUB antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of ELAVL2 recombinant protein (Accession Number: BC030692). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:110273(ELAVL2 antibody) at dilution of 1:3000

    mouse cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:110273(ELAVL2 antibody) at dilution of 1:3000

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:110273(ELAVL2 antibody) at dilution of 1:100 (under 40x lens)

    IP Result of anti-ELAVL2 (IP:Catalog No:110273, 4ug; Detection:Catalog No:110273 1:1000) with mouse cerebellum tissue lysate 4400ug.

    IP Result of anti-ELAVL2 (IP:Catalog No:110273, 4ug; Detection:Catalog No:110273 1:1000) with mouse cerebellum tissue lysate 4400ug.

  • Background
    The ELAV (embryonic lethal abnormal visual system) gene of D. Melanogaste is the the first identified member of a family of neuronal RNA binding proteins that is conserved in metazoans. The proteins in this family contain three RNA Recognition Motifs (RRM), with a hinge region separating the second and third RRMs and an optional non-conserved N-terminal region. The hinge includes signals essential for nuclear export and subcellular localization [PMID:9874760]. Elav is expressed specifically in the neurons and is required for the correct development and maintenance of the nervous system. ELAVL2 can binds RNA, and recognize a GAAA motif. In addition, it can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR[PMID:18715504,21695151].
  • References
    • Parchem RJ, Moore N, Fish JL. miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell reports. 12(5):760-73. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"