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Product Name
ELAC2 antibody
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Description
ELAC2 Rabbit Polyclonal antibody. Positive WB detected in DU 145 cells, HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 92 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
elaC homolog 2 (E. coli) antibody; ElaC homolog protein 2 antibody; ELAC2 antibody; ELC2 antibody; FLJ10530 antibody; FLJ36693 antibody; FLJ42848 antibody; HPC2 antibody; Ribonuclease Z 2 antibody; RNase Z 2 antibody; tRNA 3 endonuclease 2 antibody; tRNase Z 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of ELAC2 recombinant protein (Accession Number: NM_018127). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
DU 145 cells were subjected to SDS PAGE followed by western blot with Catalog No:110271(ELAC2 Antibody) at dilution of 1:300
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Background
Putative prostate cancer susceptibility protein (ELAC2) is encoded by HPC2/ELAC2 gene. HPC2 is a potential prostate cancer predisposition gene playing a role in genetic susceptibility to prostate cancer.It is a zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity and probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC).
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References
- Brzezniak LK, Bijata M, Szczesny RJ, Stepien PP. Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs. RNA biology. 8(4):616-26. 2011.
- Mineri R, Pavelka N, Fernandez-Vizarra E, Ricciardi-Castagnoli P, Zeviani M, Tiranti V. How do human cells react to the absence of mitochondrial DNA? PloS one. 4(5):e5713. 2009.
- Bogenhagen DF, Martin DW, Koller A. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell metabolism. 19(4):618-29. 2014.
- Jourdain AA, Koppen M, Wydro M. GRSF1 regulates RNA processing in mitochondrial RNA granules. Cell metabolism. 17(3):399-410. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"