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Product Name
DYX1C1 antibody
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Description
DYX1C1 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, rat testis tissue. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 48kd
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DYX1 antibody; DYX1C1 antibody; DYXC1 antibody; EKN1 antibody; FLJ37882 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DYX1C1 recombinant protein (Accession Number: NM_001033560). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:110150(DYX1C1 antibody) at dilution of 1:1000
IP Result of anti-DYX1C1 (IP:Catalog No:110150, 4ug; Detection:Catalog No:110150 1:500) with mouse testis tissue lysate 4000ug.
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Background
DYX1C1 initially was described as the first candidate gene for developmental dyslexia. The protein contains three TPR motifs and one p23 domain, all commonly known for their protein-protein interactions. It also has been linked to neuronal migration. Recently it has been reported that the expression of DYX1C1 protein is lost in breast cancer and patients who have lost DYX1C1 expression have a poor overall survival,indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.
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References
- Tarkar A, Loges NT, Slagle CE. DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nature genetics. 45(9):995-1003. 2013.
- Tammimies K, Vitezic M, Matsson H. Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins. Biological psychiatry. 73(6):583-90. 2013.
- Tammimies K, Tapia-Páez I, Rüegg J. The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation. Molecular endocrinology (Baltimore, Md.). 26(4):619-29. 2012.
- Rosin G, Hannelius U, Lindström L. The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer. BMC cancer. 12:79. 2012.
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