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Product Name
DYNC2LI1 antibody
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Description
DYNC2LI1 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, human kidney tissue. Observed molecular weight by Western-blot: 40 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CGI 60 antibody; D2LIC antibody; DKFZp564A033 antibody; DYNC2LI1 antibody; LIC3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DYNC2LI1 recombinant protein (Accession Number: NM_001193464). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:110139(DYNC2LI1 antibody) at dilution of 1:500
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Background
DYNC2LI1 (D2LIC, LIC3) is a member of cytoplasmic dynein 2 complex that is required for retrograde transport. It is ubiquitously expressed with high expression levels in brain, kidney, lung and testes. In mammalian cells, DYNC2LI1 is localized to centrosomal region Mutations in DYNC2LI1 disrupt cilia function and cause various skeletal ciliopathies.
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References
- Ichikawa M, Watanabe Y, Murayama T, Toyoshima YY. Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro. FEBS letters. 585(15):2419-23. 2011.
- Kessler K, Wunderlich I, Uebe S. DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects. Scientific reports. 5:11649. 2015.
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