Dynamitin antibody

Dynamitin antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Dynamitin Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, human testis tissue, mouse lung tissue. Observed molecular weight by Western-blot: 50kd

ELISA, WB, IP

Human, Mouse; other species not tested.

DCTN 50 antibody; DCTN2 antibody; DCTN50 antibody; dynactin 2 antibody; dynactin 2 (p50) antibody; Dynactin subunit 2 antibody; DYNAMITIN antibody; p50 dynamitin antibody; RBP50 antibody

Rabbit IgG

This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_001261413). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believed to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, thus extend to vesicle trafficking and membrane integrity. Dynamitin was named so because its overexpression causes dynactin complex which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is for MacMARCKS binding and residues 59-83 is responsible for calmodulin binding. This antibody is is against the N terminal 59aa of full length p50 dynamitin.

• Cheng Z, Guo S, Copps K. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature medicine. 15(11):1307-11. 2009.