DVL1 Polyclonal Antibody

Cat.#: 160544

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Product Information

  • Product Name
    DVL1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to DVL1
  • Tested applications
    WB, IHC, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    DVL1 antibody; DRS2 antibody; DVL antibody; DVL1L1 antibody; DVL1P1 antibody; dishevelled segment polarity protein 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-640 of human DVL1 (NP_004412.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
    IF 1:50 - 1:200
  • Validations

    Western blot - DVL1 Polyclonal Antibody

    Western blot - DVL1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using DVL1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 60s.

    Immunohistochemistry - DVL1 Polyclonal Antibody

    Immunohistochemistry - DVL1 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded rat testis using DVL1 antibody at dilution of 1:100 (40x lens).

    Immunohistochemistry - DVL1 Polyclonal Antibody

    Immunohistochemistry - DVL1 Polyclonal Antibody

    Immunohistochemistry of paraffin-embedded mouse testis using DVL1 antibody at dilution of 1:100 (40x lens).

    Immunofluorescence - DVL1 Polyclonal Antibody

    Immunofluorescence - DVL1 Polyclonal Antibody

    Immunofluorescence analysis of NIH/3T3 cells using DVL1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"