DTX1 antibody

DTX1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DTX1 Rabbit Polyclonal antibody. Positive IF detected in mouse olfactory epithelium tissue. Positive IHC detected in human testis tissue.

ELISA, IF, IHC

Human,Mouse,Rat; other species not tested.

deltex homolog 1 (Drosophila) antibody; Deltex1 antibody; DTX1 antibody; hDTX1 antibody; hDx 1 antibody; Protein deltex 1 antibody

Rabbit IgG

This antibody was obtained by immunization of DTX1 recombinant protein (Accession Number: XM_011538009). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Deltex homolog 1 (E3 ubiquitin-protein ligase DTX1) is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.DTX1 is conserved from Drosophila, and is expressed in a wide array of tissues, particularly in the central nervous system, testes, and endothelial cells, mainly colocalized with Notch1.It contains a RING-type zinc finger and 2 WWE domains. This antibody recognizes DTX1 protein (72kd) and it's isoforms (about 60kd).