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Product Name
DOK3 Polyclonal Antibody
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Description
Polyclonal antibody to DOK3
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Tested applications
WB, IHC
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Species reactivity
Human
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Alternative names
DOK3 antibody; DOKL antibody; docking protein 3 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human DOK3
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:10 - 1:50 -
Validations
Western blot - DOK3 Polyclonal Antibody
Western blot analysis of extracts of human notum skin, using DOK3 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"