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Product Name
DOK1 antibody
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Description
DOK1 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells. Observed molecular weight by Western-blot: 62 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
DOCking protein 1 antibody; DOK1 antibody; p62(dok) antibody; P62DOK antibody; pp62 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DOK1 recombinant protein (Accession Number: NM_001318869). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:110049(DOK1 antibody) at dilution of 1:400
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Background
The downstream of tyrosine kinase 1gene (DOK1) has emerged as a newly identified tumor suppressor gene that encodes a multi-domain adapter protein and acts as a negative regulator of signaling pathways involved in several cellular functions. DOK1 inhibits cell proliferation, down regulates MAP kinase activity, and has an opposing role in leukemogenesis and promotes cell spreading, motility, and apoptosis. (PMID: 24809689)
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