DOCK3; MOCA antibody

DOCK3; MOCA antibody

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DOCK3; MOCA Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 233 kDa

ELISA, WB

Human, Mouse; other species not tested.

dedicator of cytokinesis 3 antibody; DOCK3 antibody; KIAA0299 antibody; MOCA antibody; Modifier of cell adhesion antibody; PBP antibody; Presenilin binding protein antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_004947). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Dedicator of cytokinesis3 (DocK3) , also named as MocA and PBP , is a ~180 kDa protein involved in signaling trasduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DocK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DocK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoteing axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DocK3 plays important roles downstream of BDNF signaling in the CNS.

• Zhu X, Gao G, Chu K. Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. The international journal of biochemistry & cell biology. 61:103-14. 2015.