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Product Name
DNASE1L3 antibody
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Description
DNASE1L3 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 33kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
DNASE1L3 antibody; DNase gamma antibody; DNAS1L3 antibody; DNase I like 3 antibody; DNase I homolog protein DHP2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DNASE1L3 recombinant protein (Accession Number: NM_004944). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:109959(DNASE1L3 antibody) at dilution of 1:600
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Background
Deoxyribonuclease 1-like 3 (DNASE1L3, DNase gamma, DNase Y, LS-DNase) is member of a DNASE1 protein family that is identified by similar biochemical properties such as Ca2+/Mg2+- dependency and an optimal pH of about 7.0 as well as by a high similarity in their nucleic acid and amino acid sequences [PMID:15796714]. It is an endonuclease and cleaves double-stranded DNA (and single-stranded DNA) producing 3′-OH/5′-P ends, which is Ca2+/Mg2+-dependent and inhibited by Zn2+, but not by monomeric actin [PMID:9665719]. In addition, it has been suggested to be involved in apoptotic DNA fragmentation of thymocytes' neuronal PC12 cells, C2C12 myoblasts and of cell lines expressing the recombinant nuclease [PMID: 7957253, 9307016]
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