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Product Name
Mertansine (DM1) Monoclonal Antibody
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Description
Product has been tested in direct ELISA.
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Tested applications
ELISA
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Species reactivity
Chemical
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Alternative names
antibody
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Isotype
Mouse IgG2b, κ
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Preparation
DM1 conjugated with BSA, Protein G affinity purified
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Clonality
Monoclonal
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Formulation
PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
ELISA: 1:5,000-1:20,000
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Validations
ELISA Binding Assay of Anti-DM1 Antibody (MM56B) to different proteins.
ELISA analysis of Anti-DM1 Monoclonal Antibody with DM1-BSA, DM1-KLH, BSA, KLH and Kadcyla. Anti-DM1 Monoclonal Antibody can bind to DM1-BSA, DM1-KLH or DM1 ADC but not carrier proteins.
ELISA Binding Assay of Anti-DM1 Antibody (MM56B)
Immobilized DM1 ADC at 1μg/mL (100μL/well) can bind anti-DM1 mouse monoclonal antibody.
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Background
Mertansine (DM1) is an organic heterotetracyclic compound. Mertansine is a tubulin inhibitor which inhibits the assembly of microtubules by binding to tubulin. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) for cancer therapy.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"