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Product Name
DLX4 antibody
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Description
DLX4 Rabbit Polyclonal antibody. Positive IF detected in Hela. Positive IHC detected in human lymphoma. Positive WB detected in human heart tissue. Observed molecular weight by Western-blot: 38kd
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
DLX4 antibody; Homeobox protein DLX 4 antibody; Homeobox protein DLX 8 antibody; DLX8 antibody; BP1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of DLX4 recombinant protein (Accession Number: NM_138281). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:110000(DLX4 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:110000(DLX4 antibody) at dilution of 1:50 (under 10x lens)
Immunofluorescent analysis of Hela cells, using DLX4 antibody Catalog No:110000 at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG (green). Blue pseudocolor = DAPI (fluorescent DNA dye).
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Background
Globin genes' expression in the β-globin cluster is restricted to erythroid cells, with five different genes expressed during embryonic (e), fetal (Gγ and Aγ), and adult (δ and β) development [PMID:9461381]. Transcriptional activation of globin genes occurs not only by the binding of transcriptional activator proteins to the promoter of the gene being activated but also by a regulatory element located 6 to 18 kb upstream of the β-globin cluster, the locus control region (LCR)[PMID:8791532]. DXL4, also known as BP1, binds to two silencer DNA sequences upstream of the adult human β-globin gene and to a negative control region upstream of the adult δ-globin gene [PMID:11909945].
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