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DLG1 antibody

Cat.#: 109990

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Product Information

  • Product Name
    DLG1 antibody
  • Documents
  • Description
    DLG1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human heart tissue. Positive WB detected in mouse lung tissue, HeLa cells. Observed molecular weight by Western-blot: 120 kDa or 130-140 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Disks large homolog 1 antibody; dJ1061C18.1.1 antibody; DKFZp761P0818 antibody; DKFZp781B0426 antibody; DLG1 antibody; DLGH1 antibody; hdlg antibody; SAP 97 antibody; SAP97 antibody; Synapse assOCiated protein 97 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_004087). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:20-1:200

    IF: 1:50-1:500

  • Validations

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:109990(SAP 97 antibody) at dilution of 1:300

    mouse lung tissue were subjected to SDS PAGE followed by western blot with Catalog No:109990(SAP 97 antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:109990(SAP 97 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:109990(SAP 97 Antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of (-20oc Ethanol) fixed HeLa cells using Catalog No:109990(SAP 97 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (-20oc Ethanol) fixed HeLa cells using Catalog No:109990(SAP 97 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    DLG1, also naemd as SAP97, hDlg and DLGH1, belongs to the MAGUK family. It is essential multidomain scaffolding protein required for normal development. DLG1 may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. It regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. DLG1 is a functional regulator of Kv1.5 channel. The DLG1-MPP7 complex promotes epithelial cell polarity and tight junction formation. The antibody is specific to DLG1.
  • References
    • Westland R, Verbitsky M, Vukojevic K. Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney. Kidney international. 88(6):1402-1410. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"