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Human Cathepsin C/CTSC (His Tag) recombinant protein

Cat.#: 500923

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Product Information

  • Product Name
    Human Cathepsin C/CTSC (His Tag) recombinant protein
  • Documents
  • Description
    Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
  • Protein name
    Dipeptidyl peptidase 1
  • Protein short names
    CATHEPSIN C; CTSC; DPP1; JP; AI047818; DPPI; HMS; PALS; JPD; CPPI; PDON1; DPP-I; PLS
  • Uniprot ID
    P53634
  • Gene Name
    CTSC; CPPI
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the pro form of human cathepsin C (NP_001805.3) (Met 1-Leu 463) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human cathepsin C exists as the pro form after removal of the signal peptide. It consists of 450 amino acids and has a predicted molecular mass of 51 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCTSC is approximately 55 kDa.
  • Purity
    > 92 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GRAMC). The specific activity is >200 pmoles/min/μg.
  • Validations

    Human Cathepsin C / CTSC / DPPI Protein (His Tag) SDS-PAGE

    Human Cathepsin C / CTSC / DPPI Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"