• Development regulating peptide Hym-248 (TFA removed)

Development regulating peptide Hym-248 (TFA removed)

Not For Human Use, Lab Use Only.

Cat.#: 304370


Special Price 121.4 USD

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Product Information

  • Product Name
    Development regulating peptide Hym-248 (TFA removed)
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
  • Three letter code
  • Length (aa)
  • Peptide Purity (HPLC)
  • Molecular Formula
  • Molecular Weight
  • Source
  • Additional Information
    Hym-248 is a neuropeptide that belongs to the GLWamides family. The source of Development regulating peptide Hym-248 is hydra (Hydra magnipapillata). The GLWamides have characteristic structural features in their N- and C-terminal regions. For example, most of the peptides share a GLWamide motif at their C-termini.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • 1. Leviev I, Williamson M, Grimmelikhuijzen CJ. Molecular cloning of a preprohormone from Hydra magnipapillata containing multiple copies of Hydra-L Wamide (Leu-Trp-NH2) neuropeptides: evidence for processing at Ser and Asn residues. J Neurochem. 1997;68(3):1319-25.
    • 2. Takahashi, T.; Muneoka, Y.; Lohmann, Y.; deHaro, M.S.L.; Solleder, G.; Bosch, T.C.G.; David, C.N.; Bode, H.R.; Koizumi, O.; Shimizu, H.; et al. Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families. Proc. Natl. Acad. Sci. USA 1997, 94, 1241–1246.
    • 3. Takahashi, T.; Kobayakawa, Y.; Muneoka, Y.; Fujisawa, Y.; Mohri, S.; Hatta, M.; Shimizu, H.; Fujisawa, T.; Sugiyama, T.; Takahara, M.; et al. Identification of a new member of the GLWamide peptide family: Physiological activity and cellular localization in cnidarian polyps. Comp. Biochem. Physiol. Part B 2003, 135, 309–324.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-EPLPIGLW-Amidation
  • Chemical Formula:C46H70N10O10
  • Sequence length:8
  • Extinction coefficient:5690 M-1cm-1
  • GRAVY:0.51
  • Mw average:923.11
  • Theoretical pI:3.28
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.