DCUN1D5 antibody

DCUN1D5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

DCUN1D5 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, mouse brain tissue, rat spleen tissue, U-937 cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 28 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

DCN1 like protein 5 antibody; DCUN1D5 antibody; FLJ32431 antibody

Rabbit IgG

This antibody was obtained by immunization of DCUN1D5 recombinant protein (Accession Number: NM_032299). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Conjugation of Nedd8 to a cullin protein, termed neddylation, is an evolutionarily conserved process that functions to activate the cullin-RING family E3 ubiquitin ligases, leading to increased proteasomal degradation of a wide range of substrate proteins. Cellular neddylation requires the action of DCN1 (Defective in cullin neddylation protein 1), which, in humans, consists of five homologues designated as DCNL1-5. DCUN1D5 gene encodes the 28 kDa DCUN1 domain-containing protein 5 containing a C-terminal potentiating neddylation domain. The cellular function of DCUN1D5 needs to be explored, recently, a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, was reported to regulate hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.

• Guo W, Li GJ, Xu HB. In vitro biological characterization of DCUN1D5 in DNA damage response. Asian Pacific journal of cancer prevention : APJCP. 13(8):4157-62. 2012.