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Product Name
DCC Polyclonal Antibody
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Description
Polyclonal antibody to DCC
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Tested applications
WB
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Species reactivity
Human
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Alternative names
DCC antibody; CRC18 antibody; CRCR1 antibody; IGDCC1 antibody; MRMV1 antibody; NTN1R1 antibody; netrin receptor DCC antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human DCC
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
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Validations
Western blot - DCC Polyclonal Antibody
Western blot analysis of extracts of U-87MG cells, using DCC antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"