Cytokeratin 19 antibody

Cytokeratin 19 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Cytokeratin 19 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human appendix tissue, human breast cancer tissue, human cervical cancer tissue, human cervix tissue, human colon cancer tissue, human liver cancer tissue, human lung cancer tissue, human ovary tumor tissue, human prostate cancer tissue, human prostate hyperplasia tissue, human skin cancer tissue, human thyroid cancer tissue, human urothelial carcinoma tissue. Positive IF detected in HeLa cells, HepG2 cells. Positive WB detected in MCF7 cells, BxPC-3 cells, HepG2 cells. Observed molecular weight by Western-blot: 40 kDa, 46 kDa

ELISA, WB, IHC, IF

Human,Mouse,Rat; other species not tested.

CK 19 antibody; CK19 antibody; Cytokeratin 19 antibody; K19 antibody; K1CS antibody; keratin 19 antibody; KRT19 antibody

Rabbit IgG

This antibody was obtained by immunization of Cytokeratin 19 recombinant protein (Accession Number: NM_002276). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT19, one of type I keratins, is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Due to its high sensitivity, KRT19 is the most used marker for detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. This antibody, generated against full length KRT19 protein, also recognizes KRT17, another type I keratin homologous to KRT19.

• Vartak N, Damle-Vartak A, Richter B. Cholestasis-induced adaptive remodeling of interlobular bile ducts. Hepatology (Baltimore, Md.). 63(3):951-64. 2016.