CYR61 Polyclonal Antibody

Cat.#: 160691

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Product Information

  • Product Name
    CYR61 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to CYR61
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse
  • Alternative names
    CYR61 antibody; CCN1 antibody; GIG1 antibody; IGFBP10 antibody; protein CYR61 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human CYR61
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:1000 - 1:2000
  • Validations

    Western blot - CYR61 Polyclonal Antibody

    Western blot - CYR61 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using CYR61 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 30s.

  • Background
    Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"