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CYP2C8 antibody

Cat.#: 109692

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Product Information

  • Product Name
    CYP2C8 antibody
  • Documents
  • Description
    CYP2C8 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue.
  • Tested applications
    ELISA, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    CPC8 antibody; CYP2C8 antibody; CYPIIC8 antibody; CytOChrome P450 2C8 antibody; CytOChrome P450 form 1 antibody; CytOChrome P450 IIC2 antibody; CytOChrome P450 MP 12 antibody; CytOChrome P450 MP 20 antibody; MP 12/MP 20 antibody; S mephenytoin 4 hydroxylase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CYP2C8 recombinant protein (Accession Number: NM_000770). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human liver using Catalog No:109692(CYP2C8 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:109692(CYP2C8 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:109692(CYP2C8 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:109692(CYP2C8 antibody) at dilution of 1:50 (under 40x lens)

  • Background
    CYP2C8(Cytochrome P450 2C8) is also named as CYPIIC8, cytochrome P450 IIC2, cytochrome P450 MP-12, cytochrome P450 MP-20, cytochrome P450 form 1 and S-mephenytoin 4-hydroxylase. It belongs to the cytochrome P450 family. It is a monooxygenase involved in an NADPH-dependent electron transport pathway and a hepatic drug-metabolizing enzymes that oxidizes therapeutic drugs such as taxol and cerivastatin and endobiotics such as retinoic acid and arachidonic acid. It has 2 isoforms produced by alternative splicing.
  • References
    • Wei X, Zhang D, Dou X. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC cancer. 14:841. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"