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Product Name
CYFIP2 antibody
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Description
CYFIP2 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue, mouse brain tissue. Positive IHC detected in human gliomas tissue, human brain tissue. Observed molecular weight by Western-blot: 130 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CYFIP2 antibody; KIAA1168 antibody; p53 inducible protein 121 antibody; PIR121 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CYFIP2 recombinant protein (Accession Number: XM_011534516). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:109676(CYFIP2 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:109676(CYFIP2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:109676(CYFIP2 antibody) at dilution of 1:50 (under 40x lens)
IP Result of anti-CYFIP2 (IP:Catalog No:109676, 4ug; Detection:Catalog No:109676 1:700) with mouse brain tissue lysate 4000ug.
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Background
CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. CYFIP2 mRNA is ubiquitously expressed and particularly abundant in the central nervous system. Recently, CYFIP2 was regarded as one of the ALS potential biomarkes in non-neural tissues from amyotrophic lateral sclerosis (ALS) patients that may have direct diagnostic and therapeutic implications to the disease.
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References
- Nachmany H, Wald S, Abekasis M, Bulvik S, Weil M. Two potential biomarkers identified in mesenchymal stem cells and leukocytes of patients with sporadic amyotrophic lateral sclerosis. Disease markers. 32(4):211-20. 2012.
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